Many dosage forms and pharmaceutical technologies trace their origins to the food industry, where taste is paramount. In this blog our formulation and sensory scientists share practical concepts and techniques for developing palatable drug products.

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The Role of Sweeteners in Taste Masking

Posted by Senopsys on January 9, 2018

If you’re a Disney fan of a certain age, you probably can sing the lyrics to Mary Poppins Spoonful of Sugar Makes the Medicine Go Down. Many APIs are known to be bitter, some extremely so. The addition of flavor – orange, grape, berry, chocolate – cannot reduce bitterness as taste and smell have different perception pathways. Rather bitterness is reduced by blending with the complementary basic tastes – sweet, sour and salty – through the mechanism of taste/taste interaction. When properly blended, the result is a neutral tasting (“white”) base in which the basic tastes are not separately perceived.

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Taste Masking – There’s More Beneath the Hood than Bitterness

Posted by Senopsys on July 3, 2017

Recently, a strange noise from my car required a trip to the mechanic. Before the garage can start repairs, they need to diagnose the problem – is it a worn clutch or an exhaust? The same is true for developing palatable formulations – it’s not enough to know that it tastes “yucky” as there’s no universal “yummy” ingredient.

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Palatable Drug Products Defined – It’s More Than Yuck and Yum

Posted by Senopsys on November 18, 2016

Regulations in the United States and European Union are incentivizing (via pediatric exclusivity) and requiring the development of pediatric medicine. These regulations are designed to ensure that every new drug will be evaluated for use in pediatric patients and studied in this population when appropriate. A key requirement is the submission of detailed plan that outline

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Senopsys/BMS 2016 AAPS Presentation – A Structured Taste Masking Process for Developing Palatable Pediatric Chewable Tablets

Posted by Senopsys on November 14, 2016

Senopsys and Bristol-Myers Squibb presented results of a process used to develop palatable pediatric chewable tablet formulations for two APIs with different taste masking challenges. Development followed a two-stage design: Stage 1 – Taste Assessment to quantify the taste masking challenge. Stage 2 – Taste Optimization following a sensory-directed formulation development approach. Click here to

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What Flavor is Most Effective in Masking a Bitter Taste?

Posted by Senopsys on July 20, 2016
What Flavor is Most Effective in Masking a Bitter Taste?

Many Active Pharmaceutical Ingredients (APIs) are bitter, some extremely so. Often a formulator’s first reaction to taste masking is to add a “flavor” to the formulation to mask the bitterness. This approach to taste making is not usually successful because of differences in the physiology of taste and smell. Myth Busted: Taste and Smell are

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Developing Palatable Drug Products: A Decision Framework and Guide for CDMOs

Posted by Senopsys on July 1, 2016

Many drug actives are bitter or have other aversive attributes that require effective taste masking. Senopsys penned an article for Contract Pharma that describes the framework for developing palatable drug products advanced by the AAPS Pediatric Formulations Task Force. The framework is a decision-tree that identifies the sequence of questions that need to be answered

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