Many dosage forms and pharmaceutical technologies trace their origins to the food industry, where taste is paramount. In this blog our formulation and sensory scientists share practical concepts and techniques for developing palatable drug products.

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How Sweet is it?

Posted by Senopsys on August 29, 2018

Try this experiment next time you are in a coffee shop: Open a packet of artificial sweetener (pink, yellow, or blue) and pour it directly on your tongue. Yuck! That tasted nothing like a spoonful of sugar – so what happened? Though artificial sweeteners are widely used in pharmaceuticals, formulating with them is far from straightforward.

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Pediatric Investigation Plans: Part 1 – Determining Taste Masking Challenge

Posted by Senopsys on May 11, 2018

Regulations in the EU and US require the development of pediatric dosage forms of every new drug. Pediatric Investigation Plans (for EMA) and Pediatric Study Plans (for FDA) should be submitted early in development, but frequently are filed late and lack specificity. A savvy applicant should take a proactive approach by proposing scientific, stage-gate study plans to fulfill regulatory requirements while mitigating technical and economic risks.

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The Role of Sweeteners in Taste Masking

Posted by Senopsys on January 9, 2018

If you’re a Disney fan of a certain age, you probably can sing the lyrics to Mary Poppins Spoonful of Sugar Makes the Medicine Go Down. Many APIs are known to be bitter, some extremely so. The addition of flavor – orange, grape, berry, chocolate – cannot reduce bitterness as taste and smell have different perception pathways. Rather bitterness is reduced by blending with the complementary basic tastes – sweet, sour and salty – through the mechanism of taste/taste interaction. When properly blended, the result is a neutral tasting (“white”) base in which the basic tastes are not separately perceived.

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Trouble with Tribbles – Bringing Mini-Tablets Under Control

Posted by Senopsys on November 6, 2017

Captain’s Log, Star Date 11.6.17: Mini-tablets are taking over the market for pediatric medicines.

Many believe that all good things come in small packages – and pediatric medicines should be no exception. However, while mini-tabs are de rigueur, they may not represent the silver bullet solution they are purported to be.

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How Flavors are Created

Posted by Senopsys on September 8, 2017

To a sensory scientist “flavor” refers to all tastes, aromas, mouthfeels and textures of a product. To a formulator, a flavor is a commercial ingredient that is a blend of volatile chemicals responsible for imparting the aroma of a product. In this post, we’ll focus on the formulator’s view, describing how these commercial “flavors” are created.

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Taste Masking – There’s More Beneath the Hood than Bitterness

Posted by Senopsys on July 3, 2017

Recently, a strange noise from my car required a trip to the mechanic. Before the garage can start repairs, they need to diagnose the problem – is it a worn clutch or an exhaust? The same is true for developing palatable formulations – it’s not enough to know that it tastes “yucky” as there’s no universal “yummy” ingredient.

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Methods of Analysis Used In Taste Masking

Posted by Senopsys on May 1, 2017

Sensory analysis is a scientific discipline used to evoke, measure, analyze, and interpret those responses to products that are perceived by the senses of sight, smell, touch, taste, and hearing. In our latest blog post we describe the methods most commonly employed to guide the development of palatable, taste-masked drug products.

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Palatable Drug Products Defined – It’s More Than Yuck and Yum

Posted by Senopsys on November 18, 2016

Regulations in the United States and European Union are incentivizing (via pediatric exclusivity) and requiring the development of pediatric medicine. These regulations are designed to ensure that every new drug will be evaluated for use in pediatric patients and studied in this population when appropriate. A key requirement is the submission of detailed plan that outline

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